Article by Pharmacist Nguyen Thu Giang – Clinical Pharmacist, Pharmacy Department, Share99 Times City International Health Hub
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Zinnat is a very commonly used antibiotic for many infections with a variety of dosage forms and content suitable for many subjects and ages. The main active substance is cefuroxim, which belongs to the broad-spectrum group of cephalosporin bactericidal antibiotics with Gram-positive and Gram-negative bacteria.
1. What cases of infection is Zinnat in order to treat?
The drug Zinnat is in order for treatment in the following cases:
- Upper respiratory tract infections such as rhinotracheitis, otitis media, sinusitis, tonsillitis …
- Lower respiratory tract infections such as acute bronchitis and exacerbation episodes of chronic bronchitis.
- Urinary and genital tract infections such as renal inflammation – renal tank, cystitis.
- Un asym complications of skin and soft tissues such as boils, purulent skin diseases and impetigo
- Early Lyme disease
2. In what cases are contraintrained to use the drug Zinnat?
In addition to those who can use Zinnat drugs to treat diseases, this drug is also contrained with the following subjects:
- Patients with hypersensitivity to cefuroxime or any component of the drug
- Patients with a history of hypersensitivity (e.e., anaphylactic shock…) with penicillin or betalactam antibiotics (e.e., amoxicillin, cefalexine, cefaclor, cefixime…). For people with a history of penicillin allergy or other beta-lactam antibiotics (e.g., cefalexin, cefaclor, cefixim, etc.), there is a risk of cross-allergy to this drug.
3. Dosage of the drug Zinnat
Dosages of cefuroxime for adults and children vary in different in addition to different indicators and depend on the severe condition of the disease and the antibiotic resistance situation of the region. Accordingly, the prescribing doctor will decide the appropriate dosage for each specific case. Average duration of a 7-day course of treatment (5-10 days)
Here is a recommended reference from the manufacturer and approved by Europe in November 2019:
- For adults and children with ≥ 40kg:
With children < 40kg
The manufacturer lacks research data on the use of the drug Zinnat in children under 3 months of age. Since the drug is eliminated mainly by the kidneys, for patients with impaired renal function, the dosage of the drug will be adjusted corresponding to the degree of deterioration (evaluated by Creatinine clearance).
4. Caution when using the drug
The undesirable effects of the most common drug of the drug are headache, dizziness, gastrointestinal disorders (abdominal pain, nausea, diarrhea) and a transient increase in liver enzymes.
5. Prepared forms of the drug Zinnat
Zinnat has many forms of diet, such as film-encapsoliating tablets, oral mixed packages, and oral mixed vials suitable for each age group. For each form of diet, there are several notes when using, specifically as follows:
250mg, 500mg film-covered tablets: Should be taken after eating to absorb the drug optimally. With this form of processing, the patient should not be crushed. Therefore, the form of the member is not suitable for patients who cannot swallow whole ingredients. At that time, patients can switch to a mixed package or a mixed jar.
Zinnat 125mg/5ml mixed form: Every 5ml of the mixture contains 125mg of cefuroxime. With this form of diet, patients should take the same meal to absorb the optimal medicine. However, this product should pay special attention to the mixing of the mixture:
- Shake the dough jar so that the granules do not cling to the jar, open the lid, add 1 amount of cold water to the body of the bottle, absolutely do not use hot water or warm water to cover.
- It is necessary to leave the vial to stand still for about 1 minute so that the water is fully absorbed into the granules.
- Upside down the jar and shake well for at least 15 seconds until the granules mix well with water.
- Return the vial to its original vertical position and shake well for another 1 minute until the whole grain mixes well with water.
- Immediately put the vial in the fridge cooler (temperature 2-8°C) at least 1 hour before taking the first dose. The translation after mixing should continue to be preserved in the refrigerator cooler (temperature from 2-8°C) for 10 days.
- Always shake the vial well before taking the medicine. Do not dilute the mixture with hot water for drinking, but can be mixed with cold juice or cold milk and should be drunk immediately after mixing.
Zinnat is an antibiotic that needs to be used on a doctor's prescription to ensure that the drug is used safely, appropriately and effectively, avoiding overuse of antibiotics, causing antibiotic resistance.
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Source: Medicines.org.uk
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