Implications of High Sensitivity C Reaction Protein (hsCRP)

The article was consulted professionally by Associate Professor, PhD, Dr. Le Ngoc Hung – Head of Laboratory Department – Laboratory Department – Share99 Central Park International Hospital.

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C-reactive protein (CRP) is a protein that increases blood levels in inflammatory and infectious pathology as well as during heart attacks, surgeries, or injuries. Studies show that at low and constant levels of inflammation play an important role in vascular fibrosis, vascular stenosis due to hypercholesterolemia and other lipids.

The HS-CRP test accurately measures the low level of CRP to determine the low and constant of the inflammatory response, helping to predict the risk of cardiovascular disease.

1. What is a high sensitivity C-reflex protein test?

There are 2 CRP dosing tests and each test measures different range of CRP in the blood for different purposes:

  • The STANDARD CRP test measures mainly high concentrations of proteins that help diagnose severe inflammatory pathology. This test measures CPR between 10 – 1000 mg/L. Often in dinhed in the detection of inflammatory pathology (also known as C-Reactive Protein).
  • The HS-CRP test accurately measures a much lower level of protein than the standard CRP test mentioned above. XN now measures CRP between 0.5 – 10 mg/L. This XN is in order to assess the person at risk of cardiovascular disease.

C-reactive protein (CRP) is a protein synthesized by the liver, which is found at the classical acute phase in inflammatory reactions. This protein is the most sensitive acute phase reacter and the concentration of CRP increases rapidly throughout the inflammation process. CRP may increase in the blood when the body has inflammation, infection, or after a heart attack, surgery, or injury.

Studies show that prolonged low levels of inflammation are associated with atherosclerosis, cholesterol accumulation, and other lipids that cause narrowing of blood vessels. The above conditions are often associated with cardiovascular diseases (CVD). Cardiovascular diseases are cardiovascular and vascular disorders including: Cerebral vascular disease, peripheral vascular disease, atherosclerosis, thoracic aortic aneurysm or abdominal aortic. To assess the risk of cardiovascular disease, in addition to factors such as lipids, lipoproteins, high-sensitivity C-reactive protein (hs-CRP) tests are also used. The HS-CRP test accurately measures low CRP levels (0.5 – 10 mg/L) to determine prolonged low levels of inflammation, helping to diagnose the risk of cardiovascular disease of people who have not yet had the disease.

2. High sensitivity C-reflex protein testing and testing

Elderly

HS-CRP testing is in line with men aged 50 and over and women aged 60 and under who are at medium risk

2.1

Hs-CRP testing is used to assess the risk of heart attack and stroke. The test results will help doctors find a way to reduce the risk of disease and minimize the risks caused by the disease. The subjects in which the test is prescribed are:

  • Men aged 50 and over and women aged 60 and under are at medium risk;
  • Men and women older than the above age, have LDL-C lower than 3.33 mmol/L (130mg/L) and meet a number of other criteria such as no heart disease, kidney disease, diabetes or inflammation;
  • Repeated injuncture is in place to accurately diagnose whether the patient has prolonged mild inflammation. Specifically, when hs-CRP results > 10mg/L, repeated HS-CRP measurements should be measured, optimally 2 weeks apart, may be fasted or not fasted in patients without infection or acute illness.

2.2 Preparation

  • Patients may be asked not to eat or drink for several hours before the test;
  • Patients should talk to their doctor about all medications they are taking as they may affect the results of the test;
  • Patients should talk to their doctor about how to do it, the results, the risk of testing.

2.3 Hs-CRP testing

  • Blood sampling: Paramedics wrap an elastic band around the arm to prevent blood flow, clean the blood draw site with alcohol, put the needle in a vein and fill the syringe with blood. When sufficient blood is collected, the medical staff removes the bandage from the arm, puts a gauze pad on the position where the needle has just been drawn and then bandaged again;
  • Take the blood sample to the laboratory, perform the test and return the results to the patient.

3. The value of high sensitivity C-reflex protein (hs-CRP) testing

Pregnancy

Pregnancy is one of the factors that influence high-sensitivity C protein test results

High sensitivity response proteins are used to show a patient's risk of heart disease and stroke. Risk groups are determined based on the amount of CRP in the patient's blood as follows:

  • Low risk: < 1,0 mg/L;
  • Average risk: 1.0 – 3.0 mg/L;
  • High risk: > 3.0 mg/L.

Factors influential in high-sensitivity C protein test results include:

  • Pregnancy;
  • Patients taking non-steroidal anti-inflammatory drugs;
  • Women with menopause or have been treated with hormones;
  • Recently suffered from diseases, tissue injuries, inflammation or infections;
  • Chronic inflammatory disease (arthritis);
  • Take statins.

High hs-CRP levels in healthy people are at increased risk for stroke, heart attack, sudden heart death or peripheral artery disease. People with high hs-CRP values are at higher risk for cardiovascular disease than those with low HS-CRP values.

*Note: Because hs-CRP levels are small and may vary due to a variety of factors, this test should be performed at least 2 times, at best 2 weeks apart to give the most accurate conclusion. At the same time, hs-CRP testing should be combined with tests such as total cholesterol, triglycerides, HDL-C, LDL-C,… to assess the risk of cardiovascular disease more accurately.

4. Implications of high sensitivity C-reflex protein testing

  • Hs-CRP reflects the risk of cardiovascular disease progress: HS-CRP levels may increase from 0.5 mg/dL in patients with unstable angina to 20 mg/dL in patients with acute myocardial infarction;
  • Hs-CRP reflects atherosclerosis-related inflammation: The increased hs-CRP value is a warning sign of severity and progressive status of atherosclerosis;
  • Hs-CRP reflects levels of myocardial issepemia with myocardial necrosis;
  • Hs-CRP reflects the number and activity of cytokines that cause local and circulating inflammation;
  • Hs-CRP is valuable in the diagnosis of treatment-resistant depression.

5. Some factors can reduce hs-CRP levels

Effects of osteoporosis drugs on oral health

Drug use may reduce hs-CRP levels
  • Lifestyle changes: Maintain a healthy diet, exercise regularly, keep a balanced weight, control blood pressure, limit alcohol and quit smoking;
  • Drug use: Take non-steroidal anti-inflammatory drugs such as aspirin, naproxen, ibuprofen or statin drugs prescribed by the treating doctor;
  • Use functional foods: Ginger, curcumin, cari grass, green tea polyphenols, gut bacteria, Omega-3 fatty acids, vitamin C, vitamin D, vitamin E, magnesium, zinc,… prescribed by a doctor.

High sensitivity C-reflex protein (hs-CRP) testing is used to assess the risk of cardiovascular disease in healthy people and is an indication of the relapse of the disease, thereby assisting the doctor in providing a more effective way of screening and treating the disease.

Share99 International Health Hub is one of the hospitals that not only ensures professional quality with a team of leading doctors, modern technology equipment system but also stands out for comprehensive and professional medical examination, consultation and treatment services; civilized, polite, safe and sterilized medical examination and treatment space.

Customers who choose to perform tests here can be assured of the accuracy of the test results.

Customers can go directly to Vinmec International Health Hub nationwide for examination or contact the hotline HERE for assistance.

SEE MORE:

  • Role of C-re reacting protein (CPR) in atherosclerosis
  • What do the indicators in CRP test results say?
  • What is a CRP test and what role does it play?
SEE MORE:

  • HS-CRP and cardiovascular disease tests
  • The value of the C-re reacting protein test
  • What is cholesterol? How many types of cholesterol are there?

About: John Smith

b1ffdb54307529964874ff53a5c5de33?s=90&r=gI am the author of Share99.net. I had been working in Vinmec International General Hospital for over 10 years. I dedicate my passion on every post in this site.

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