Hargraves cell (LE cell) test in diagnosis of systemic lupus erytheb erythebies

The Hargraves cell test, also known as a LE cell test, is a subclinical type of test used for people with suspected systemic lupus erythebatic disease to accurately diagnose the disease.

1. Systemic Lupus erythem erythem

Lupus is defined as chronic inflammatory automatoid disorder. Lupus inherently acts as a protection of the human body from infection and creates an immune response that is not suitable for agency tissue. Lupus often causes certain effects on the skin, joints, blood vessels, internal organs such as kidneys, heart, brain lungs. Lupus is of many types but the most common is systemic lupus erythecus or, more briefly, Lupus erythecies that affect many parts of the human body.

Lupus erythemosus is more common in women than men, common in Africa, Asia, Spain and Native American populations. The disease has a higher probability of encountering in people between the ages of 15 and 45, but there are still cases where younger children or older adults still have systemic lupus erythem.

As of now, the cause of systemic lupus erythebity has not been clearly found and fully studied. Some information suggests that Lupus erythem erythees are heredity and triggers associated with the surrounding environment. Other studies have found that systemic lupus erythemosis is caused by medication or infection, viruses, or also hormones. Systemic lupus erythematitis is often accompanied by other autoimary disorders such as hemolytic anemia Sjogren's syndrome, thyroiditis or semia hemorrhage.

Lupus erytheblast cells, also known as LE cells first described by Hargraves, should also be called Hargraves cells. Lupus erytheblastoma cells are found in the bone marrow of patients with systemic Lupus erythebitis. The scientists then studied the biology of these LE cells, making up them by giving the blood of people with Lupus erythematous direct contact with their own plasma during the right time and temperature. From there, find out the type of test called Hargraves cell test or LE cell test that plays an important role in the diagnosis of systemic lupus erythebity.

Systemic Lupus erythem erythem

Causes of Systemic Lupus Erythem Erythem disease have not yet been clearly found

2. Hargraves Cell Test

Those who present with the following symptoms will be included in the group suspected of contracting systemic Lupus erythebatic disease and prescribed a Hargraves cell test to reinforce the diagnosis:

  • Muscle and joint pain
  • Arthritis, inflammation of one or more joints
  • Red rash, butterfly wing-shaped rash on the nose, cheeks
  • fever
  • Long-term fatigue
  • Swelling of the glands in the body
  • Increased sensitivity to sunlight
  • Symptoms of Raynaud's phenomenon
  • Hair loss
  • Chest pain
  • Symptoms of anemia such as blurred vision, eyes, pale mucous membranes …
  • Mouth sores
  • Inflammation of the muscles such as kidneys, lungs, heart, pericard membranes, central nervous system, blood vessels …

LE cell testing will be performed on patients with the above symptoms and performed by taking the following samples:

  • Heparin-proof anti-freezing bone marrow
  • Heparin-proof veins
  • Intravenous blood anti-coaulation with Oxalate
  • Fibrin Separation Vein Blood
  • Lumpy vein blood
  • LE factor and other cells on the patient's body.

When taking a Test of Hargraves Cells, bone marrow sampling causes a lot of pain for patients, so currently, intravenous blood is often the more common option for testing. The patient's veins, which are not used for treatment, will be clotted and serum removed, transferred through a steel mesh and centrifugal 5 minutes of Buffy layering and finally spread on the glass blue for le cell testing to diagnose systemic lupus erythematous lupus.

Hargraves cells (LE cells)

LE cell test diagnoses systemic lupus erytheb erythebies

A standard of 1 smear will be taken to find le cells and if there are ≥ 10 LE cells found in 15 minutes of observation of that type, along with the appearance of aplasmosis as well as extra-cell nuclear mass will test positive when tested.

If the result is contrary to the above, it is negative and the doctor can conclude that the patient does not have systemic lupus erythety. The Hargraves cell test is positive when 2% to 30% of LE cells are seen on a white blood cell micro-field. However, in order for the test to be accurate, it depends on a number of factors such as technique, observation of the technician. During LE cell testing, mistakes should be avoided with Tart cells that are monotybular, have solids and sizes that are not as large as LE cells.

LE cell testing is not only positive for systemic lupus erythematosus, but also in other conditions such as rheumatoid arthritis, chronic hepatitis, sclerosis, dermatitis, hemolytic anemia, Hodgkin's disease … and those who use certain drugs such as Phenylbutazone, Hydralazine … so the ability to test positive LE cells for Lupus erytheb disease is only about 50% to 75%.

Hargraves cell testing is a subclinical technique used to diagnose systemic lupus erythebical disease. However, not all positive cases of LE cell testing are diseased, so it is necessary to rely on other factors as well as other subclinical results to support the diagnosis of systemic lupus erythebity.

SEE MORE:

  • Should lupus erythe erythem patients become pregnant and give birth?
  • What is lupus erythem erythem? The danger and complications of the disease
  • Should lupus erythe erythem patients become pregnant and give birth?

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SEE MORE:

  • How is lupus erythe erythem treatment, is it curable?
  • The dangers of lupus erythem
  • Caution when Lupus erythematitis complications

About: John Smith

b1ffdb54307529964874ff53a5c5de33?s=90&r=gI am the author of Share99.net. I had been working in Vinmec International General Hospital for over 10 years. I dedicate my passion on every post in this site.

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