Male infertility AZF removal test

With the development of genetics, scientists discovered the role of the AZF gene in spermatodes in men. Azf removal test is an important male infertility test, which helps doctors diagnose and navigate during treatment .

1. What does AZF mean?

AZF stands for Azoospermia factor, which is an area located on the long branch of the Y sex chromotype, which contains many important genes that govern spermatoly in men. These genes are distributed in three regions: AFZa, AFZb, and AFZc. When afz deletion mutations occur, depending on which AFZ region is affected, it will have different effects.

If a segment deletion mutation occurs in the AZFa region, it will lead to complete infertility and Sertoli syndrome (the testicles have only cells that help support sperm growth, not sperm). If paragraph deletion occurs in the AZFb region, deleting the small paragraph will appear halfway spermatoo, deleting the large paragraph will lead to infertility.

The AZFc region is about 1.4 Mb in size near the heterochromic region. Mutations present in the AZFc region can cause diverse manifestations in men, sperm may be normal, mildly mild, low in severe crystallization, or infertility.

In some cases, a combination deletion such as deleting the AZFb+ c area, deleting azf a+ b + c.

2. Why do AZF removal tests be performed?

Male infertility

AzF removal test will help determine whether the cause of infertility in men is a mutation that deletes the AZF region segment on the Y chromochromo

In the causes of male infertility due to heredity, the azf deletion mutation is the second leading cause of infertility after Klinefelter Syndrome. Performing an AZF removal test will help determine whether the cause of infertility in men is a mutation that deletes the AZF region segment on the Y chromochromo.

Due to the influence of paragraph deletion mutations that occur in different AFZ regions will cause different effects on the function of reproduction in men. If male infertility due to a segment deletion mutation appears in the AZFa region, AZFb region, or the mutation deletes the combination, the man will not be able to have sperm and cannot have children. The treatment should stop because it will not bring results and be costly for the patient. However, the segment deletion mutation occurs in the AZFc region, 70% of cases can find sperm flow cells, these cells will be biosed, sucked then cultured in special environments to distinguish into sperm. These sperm will be used for in vism in vism fertilization or for medical treatment of sperm stimulation.

Thus, azf removal test is an important male infertility test, helping to determine the cause of infertility, directing doctors to appropriate treatment directions, reducing the cost of ineffective treatment for patients. When a patient with a mutation deletes the AZF segment successfully treated and can give birth, if a girl is born, there will be no Y sex chromotype so it will not be affected, however if a son is born, he will have the genetic mutation Y and later will also suffer from male infertility. Therefore, AZF removal testing is the basis for doctors to give genetic advice to patients, help patients understand their condition and choose the right treatment.

3. What cases is AZF removal testing in point for?

AZF removal testing is in the following cases:

  • Men with infertility, no sperm in semen cause not blockages or severe sperm mitigation (the amount of semen containing less than 5 million sperm /ml).
  • Before the surgery to remove the varicose dilation of the sperm in patients with varicose dilation, the AZF test is used for screening for the doctor to decide whether to perform this surgery for the patient, because if the cause of infertility is caused by a mutation that removes the AFZ segment, the removal of the vascular varicose dilation of the spermatome cannot improve sperm weakness.
  • In the family there are brothers, brothers who have been erased by mutations, family history of repeated miscarriages, malformations or intellectual retformations.

4. Where should AZF removal testing be performed?

RealTime-PCR or QF-PCR are technologies that are currently used to perform AZF removal tests. These are modern technologies, bringing high accuracy, the patient will be given a blood sample and receive results in 2-3 days.

The Center for Assisted Reproduction – Share99 International Health Hub brings together a team of leading experts in the field of Obstetrics and Gynecology, Southern Medicine in the country and internationally, a team of doctors trained in the world's leading countries in medicine such as the US, Singapore, Japan, Australia and world-famous assisted reproduction centers. With a high level of expertise and experience, the team of experts at Share99 Fertility Center has the ability to deploy comprehensively and comprehensively the most advanced assisted reproduction techniques today, helping to realize the dream of parenthood of hundreds of families across Vietnam.

Male infertility

Share99 Fertility Center has the ability to deploy comprehensively and comprehensively the most advanced assisted reproduction techniques today

For direct advice, please click hotline number or register online HERE. In addition, you can register for remote consultation HERE

SEE MORE:

  • Mutations lose AZF region segment on Y chromoth in male infertility
  • What are the normal semen test results?
  • Female and Male Hormones Tests: What to Know

About: John Smith

b1ffdb54307529964874ff53a5c5de33?s=90&r=gI am the author of Share99.net. I had been working in Vinmec International General Hospital for over 10 years. I dedicate my passion on every post in this site.

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