The article was consulted professionally by Associate Professor, PhD, Dr. Le Ngoc Hung – Dean and Dr. Bui Thi Hong Khang – Laboratory Department – Share99 Central Park International Hospital.
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APTT testing or activated part-activated thromboplastin time test is one of the hematological tests performed during regular medical examinations, liver function examinations, hemolytosis or mandatory tests before surgery.
1. What is a thromboplastin APTT test?
APTT (activated partial thromboplastin time) also known as partial thromboplastin activation time test has the effect of surveying the calci recovery time of citrate plasma after incubation with moderate amounts of kaolin (contact factor activation) and cephalin (subsedive factor 3 thromboplastin) to help accurately assess the factors of endosumantological coaulation.
Thromboplastin (factor III) released by the lesion tissue reacts with prothrombin along with calci (IV) that produces thrombin, causing the fibrinogen to convert into fibrin (I) which will participate in the coaulation process.
2. When to perform APTT testing?
As a heath hem hem bleeding assessment test, a part APTT test will need to be performed in the following cases:
- Patients who need surgery or need hem bleeding assistance during APTT testing will help to accurately tell if the patient's ability to bleed is abnormal to come up with a remedy
- Diagnosis of blood clot disorders and the degree of disorders in this pathology
- Perform before surgery to prepare medications to support the patient if necessary.
3. Results of the test and implications
APTT of normal plasma varies from 25-35 seconds depending on the type of cephalin-kaolin and the technique used by the laboratory.
The results of the test are insular by the ratio of disease/evidence:
- rAPTT = APTT disease/APTT
- The normal rAPTT is between 0.85-1.2.
If prolonged APTT means that the sample lasts more than 8 seconds or rAPTT >1.2, the patient has endopermed blood clot disorder (freezing) due to:
- Congenital factor deficiency (hemophilia,…)
- Due to the blood coaulation factor that has been consumed lies in the coaalysis syndrome scattered in the vessels, fibrous fibrosis
- Severe liver failure does not synthesize factors
- Because there are endertherulation inhibitors in the blood
- Patients treated with standard heparin.
4. Factors affecting the error of the test
4.1 Due to specimens
- Blood sample clot, wrong anti-freezing rate or improper anti-freezing substance, damaged anti-freezing substance, heparin infection due to blood donation process
- Turbid plasma or rupture of red blood cells
- Blood samples leave more than 4 hours from the moment of blood is taken.
4.2 Due to means and chemicals, techniques
- Due to the amount of CaCl-2M/40 and cephalin-kaolin is not guaranteed, past the storage time
- Plasma samples do not take plasma collections or take from fewer than 5 people
- Non-clean test tubes
- Broken pipettes, not guaranteed in volume
- Incorrect blood clot analyzers
- The implementer does not follow the correct process, reads and miscons calculates the result.
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SEE MORE:
- The formation of blood clots in cerebral vascular accidents
- How does a blood clot form in a vein?
- Is it possible to have an amniotic test to diagnose hematoma?
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