Acute renal tubitis: Signs, complications

Acute renal tubular inflammation is an interbular condition in which the renal tubular is necrotic and damaged. Patients with acute renal tubular inflammation if not detected and treated in time may experience dangerous complications of tubular inflammation, even leading to death.

1. What is acute renal tubitis?

Acute renal tubitis, also known as acute interstitial inflammation, acute renal tubular necrosis, is a condition where the inter-cell of the renal tubular is damaged, necrosis. Acute renal tubitis is the cause of acute renal failure, which, if not detected and treated, causes serious complications and can lead to death.

2. Causes of acute renal tubular inflammation

Acute renal tubitis is caused by many causes, which are classified into the following 3 main groups:

  • Acute renal tubitis caused by anemia: Anemia in the kidneys is the leading cause of renal tubular necrosis. The causes of long-term decrease in renal perfusence cause anemia in the kidneys that can come from before the kidneys or in the kidneys. In particular, pre-kidney causes include cardiac shock, shock due to a decrease in blood volume (after surgery, injury, burns, miscarriage, abortion), shock caused by infection or intoxication. The cause in the kidneys is mainly due to drug shock or the components of the drug (non-steroidal anti-inflammatory drugs, antitensive drugs, …).

vascular medicine

Ingredients in the drug can cause poisoning in the kidneys
  • Acute renal tubular inflammation due to poisoning: Drug-infected poisoning (aminosides, neomycin, gentamycin, kanamycin, streptomycin; cisplatin, cyclosporine, interferon; anesthesigens;…), endococular pigmentation, muscle pigmentation; chemicals (carbon tetrachloride, metylic tincture,…), natural toxins (found in some seafood species and organisms such as toads, carp,…) can directly affect renal tubular cells or indirectly affect the vascular mechanism, causing renal anemia and leading to inflammation of the renal tubular.
  • Allergic acute renal tubular inflammation: Due to allergies some drugs such as non-steroidal anti-inflammatory drugs, diures, cimetidin, methicillin, penicillin, …

3. Signs of acute renal tubular inflammation

Acute renal tubitis is a manifestation of acute renal failure, which in some cases due to poisoning may be accompanied by acute hepatitis. In fact, the disease is usually detected through some typical symptoms such as oliguria, anuria, or through complications of the disease such as increased blood pressure, pulmonary edema that causes out-of-cell fluid retention, or uremic syndrome in the blood, electrolysis disorders,…

Depending on the stage, the signs of the disease vary. Progressive renal tubitis progresses through the following 5 specific stages:

  • New stage of infection: Depending on the cause of the disease, the duration of the period will vary. If due to shock, hemorrhage, the disease appears suddenly and acutely, if it is caused by poisoning, the time will be slow and prolonged.
  • Initial stage of oliguria, anuria: This stage usually appears in about 1-3 days. At this stage, the patient has signs of peripheral fluid retention such as weight gain, shortness of breath, exertion breathing, peripheral edema. After these signs are manifestations of gastrointestinal disorders, hypocundice hemorrhage.

Is it ominous to have trouble breathing after eating full

Signs of shortness of breath in patients with severe renal failure
  • True stage of oliguria, anuria: If the disease is not detected and treated in a timely manner at the initial stage, patients with acute renal tubular inflammation begin to turn to a real oliguria or anuria. There are also typical signs of hememia syndrome. The duration of the progress of this period is about 7-21 days.
  • Urinary phase: This stage may appear earlier or at the third week of the sign of anuria. Signs of this stage are that the patient begins to have a large amount of urine, which increases gradually.
  • Stage of renal rehabilitation: The renal function of the patient recovers with normal ure, creatinine indicators.

4. Complications of acute renal tubular inflammation

In the process of progress, acute renal tubitis can cause a number of body complications such as:

  • Cerebral edema, convulsions
  • Acute pulmonary edema
  • Cardiovascular failure

However, in some other cases, there are complications in the renal tubular to varying degrees, due to damage in different segments. Mild complications may be flattening, inter-renal tubular dilation, especially in the disused tubular, inter-cell necrosis of the renal tubular, necrosis of renal tubular cells that lose its material and dilation. Severe complications may be necrosis or rupture of each renal tubular passage.

Pulmonary edema

Acute pulmonary edema due to complications of acute renal tubular inflammation

Patients with acute renal tubular inflammation should be detected and treated in a timely manner. During and after the treatment should follow the instructions of the treating doctor to quickly recover.

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About: Minh Quynh

b1ffdb54307529964874ff53a5c5de33?s=90&d=identicon&r=gI am the author of I had been working in Vinmec International General Hospital for over 10 years. I dedicate my passion on every post in this site.


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