The role of the eGFR test in the probe of the dialysis function of the kidney

The kidneys are the body that help the body perform two tasks of excreting and end of end of the end. There are various methods for calculating the ability of the kidneys to function. In particular, the measurement of the level of dialysis eGFR is the best test to probe the dialysis function of the kidney.

1. Tests to probe kidney function

The kidneys are the body that is meant to survive with the role of conditioning the body's home lip balance. How many methods are there to probe the function of the causity? The kidneys need a lot of functions to perform their tasks, so there are also many different solutions that help probe kidney function, namely:

  • Measurement of inulin clearance, manitol, sodium thiosulphat or endosumantate creatinine;
  • Estimate the creatinine clearance system through serum creatinine levels;
  • Evaluation of the level of dialysis by measuring the concentration of b2-microglobulin;
  • Measure the level of dialysis of the codification using the radio is iseter method.

However, each test only reflects some of the functions of the kidney, not the whole. These tests probe kidney function, although very valuable, but are also influenced by many factors both inside and outside the kidneys. Therefore, when analyzing the results of each french experiment, it is necessary to pay attention to this characteristic.

Learn a test to evaluate the dialysis of the kidneys

Bridges have important functions

2. What is the eGFR solution?

eGFR stands for estimated Glomerular Filtration Rate. This value shows the degree to which the kidneys filter waste out of the bloodstream and helps identify kidney damage if any. Despite various tests to probe kidney function, eGFR is still considered the best measure of renal function. If the dialysis of the kidneys is higher, the better the kidneys work, usually around 90 – 100 ml /min.

In the event that the doctor requires a blood test to know more about renal function, the eGFR will be calculated by the laboratory and return the results. To accurately calculate the functioning of the kidneys, experts have formulated a special GFR estimating formula with the following 3 factors:

  • Age;
  • Gender;
  • Creatinine waste levels in the blood.

formula:

eGFR (mL/min/1.73m2) = 186.SCr-1,154.Age-0.203. (0.742 for females). (1.21 for African Americans)

In which SCr is the concentration of creatinine in the blood (mg/dL). The kidneys usually remove creatinine in the blood before excreting it in the urine, doctors said. Therefore, when renal function decreases, there will be more creatinine left in the blood.

vai-tro-cua-dinh-luong-creatinine-in-mau-body-1

Creatinine in the blood is analyzed

Formula 1: Based on the Creatinine index in the blood and urine

Take 24-hour urine to measure the volume and amount of creatinine excreted. At the same time measure the concentration of creatinine in the blood collected in the middle of the period of urine collection.

CrCl (mL/min) = (UCr.Vn)/(SCr.T)

Of which:

  • CrCl: Creatinine clearance
  • Ucr: Creatinine concentration in urine (mg/dL)
  • V urine: Volume of urine taken (mL)
  • SCr: Blood creatinine levels (mg/dL)
  • T: Urine collection time (minutes)

Formula 2: Corkroft-Gault for adults

To avoid calculating the wrong creatinine clearance value, the researchers formulated different estimative methods from the creatinine values in the serum and based on patient characteristics.

For adults 18 years of age and older and not too obese, the popular recipe recommended by Cockcroft and Gault is as follows:

Male: Estimated CrCl =[(140 – tuổi).cân nặng] /(72.SCr)

Female: Estimated CrCl [(140 – tuổi).cân nặng]= /(72.SCr)

Of which:

  • Estimated CrCl: Estimated creatinine clearance (mL/min)
  • Age: In years
  • Weight: In kg
  • SCr: Serum creatinine concentration (mg/dL)

In females, the above formula needs to be equal to 0.85 because women weigh less than men, so less creatinine produced per day.

Laboratory

Testing is carried out at reputable medical facilities

Formula 3: Based on mdrd formula

MDRD Equation – Modification of Diet in Renal Disease:

GFR (mL/min/1.73 m2) = 175 × (Scr)-1,154 × (Age)-0.203 × (0.742 for females) × (1,212 for Africans)

Of which:

  • eGFR: Estimated dialysis level;
  • SCr: Blood creatinine levels (mg/dL);
  • Age: Patient age.

3. How to read eGFR results

Normally depending on the laboratory, GFR results can be accurately reported as mL/min/1.73m2 (if eGFR < 90) hoặc hiển thị > 90 mL/min/1.73m2.

Example:

  • Result 105: Can be displayed as 105 mL/min/1.73m2 or ≥ 90 mL/min/1.73m2
  • Result 67: Shown at 67 mL/min/1.73m2

3.1. In case the result > 60 mL/min/1.73m2

Renal function is normal or near normal, but there is still a risk of kidney damage or kidney disease. Therefore, patients still need to continue monitoring, especially those with high risk factors.

There are also cases where the patient is diagnosed with chronic kidney disease (CKD) if signs of kidney damage appear and last more than 3 months. If there are no abnormalities, it is recommended to monitor renal function while following the advice of a doctor about a healthy lifestyle.

Medical examination

When the results are abnormal, the doctor is the one who gives you advice

3.2. Case results < 60 mL/phút/1,73m2

Shows that kidney function has been lost somewhat. To confirm, your doctor may request a blood test again, and monitor the change in eGFR to see if the condition is progressing rapidly or slowly.

Diagnostic signs of chronic kidney disease (CKD) include:

  • GFR results below 60 mL/min/1.73m2 for more than three months;
  • Some signs of kidney damage: Albuminuria (albumin in urine), urinary blood (blood in the urine), blood pressure, diabetes, ultrasound results or abnormal kidney bios.

4. Stages of Chronic Kidney Disease (CKD)

Depending on the eGFR, renal function will be classified into the following stages:

  • Phase 1: Normally ≥ 90 mL/min/1.73m2
  • Phase 2: Mitigation between 60 – 89 mL/min/1.73m2
  • Phase 3:
    • 3a: Mitigation – medium between 45 – 59 mL/min/1.73m2
    • 3b: Medium – strong reduction between 30 – 44 mL/min/1.73m2
  • Phase 4: Sharp decrease between 15 – 29 mL/min/1.73m2
  • Phase 5: Reduce below 15 mL/min/1.73m2 or start dimming

eGFR and albuminuria results are coordinated to provide an overview of the ability of the kidneys to function, from which the doctor will decide on the best treatment. The choice of treatment also depends on the cause of the kidney damage. In particular, controlling diabetes and high blood pressure can help slow or prevent the disease from progressing more severely. This also limits the risk of other health problems, such as heart attacks and strokes.

Register for medical examination

When your health is abnormal, you should visit a medical facility for a visit

In summary, how to measure the level of dialysis is the most important solution that probes the dialysis function of the kidney. The estimated level of renal dialysis eGFR is the volume of initial dialysis (primary urine) filtered by the globe in a unit of time. Based on the eGFR results index and some other relevant tests, the doctor will understand the state of functioning of the kidneys to give diagnosis and treatment, or useful tips for patients.

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  • Learn a test to evaluate the dialysis of the kidneys
  • What is estimated dialysis (eGFR)?
  • How much dialysis is normal?
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About: John Smith

b1ffdb54307529964874ff53a5c5de33?s=90&r=gI am the author of Share99.net. I had been working in Vinmec International General Hospital for over 10 years. I dedicate my passion on every post in this site.

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