Pentaxim 0.5ml vaccine (France)

The article was consulted professionally by Specialist Doctor II Huynh Thi Diem Thuy – Vaccine Consultant, Pediatrics – Newborn Department, Share99 Central Park International Health Hub.

The 0.5ml Pentaxim vaccine is manufactured by the French firm Sanofi. Pentaxim 0.5ml is a 5-in-1 vaccine that prevents Diphtheria – Tetanus – Whooping Cough – Polio – Hib.

1. origin

The 0.5ml Pentaxim vaccine is manufactured by the French firm Sanofi. The unit has been licensed to supply vaccines in Vietnam by the Drug Administration of Vietnam, Ministry of Health signed on 28/08/2018 according to the dispatch No. 16600/QLD-ĐK.

2. Packing size

  • Box of 1 vial, 1 dose of freezer vaccine and 1 syringe pump with needles attached, each preloaded syringe 1 dose (0.5 ml) of mixed vaccine
  • Box of 1 vial, 1 dose of freezer vaccine and 1 syringe pump without needles, each preloaded syringe 1 dose (0.5 ml) of mixed vaccine, accompanied by 2 needles
  • Box of 10 vials, 1 dose of frozen vaccine and 10 syringe pumps with needles attached, each preloaded syringe 1 dose (0.5 ml) of mixed vaccine
  • Box of 10 vials, 1 dose of frozen vaccine and 10 syringe pumps without needles, each preloaded syringe 1 dose (0.5 ml) of mixed vaccine, accompanied by 20 needles.

3. Form of diet

The free powder vaccine dries and the vaccine is mixed, re-re-established as an injection mixture. PENTAXIM consists of frozen powder in vials and opaque white coeptic mixtures loaded in injection pumps.

4. Specify

PENTAXIM is used to help protect diphtheria – Tetanus – Whooping cough – Polio and prevent invasive infections caused by Hib – Haemophilus influenzae type B (including meningitis, sepsis,…) in children 2 months and older.

This vaccine does not work against infections caused by other Haemophilus influenzae types or meningitis caused by other microorganisms.

5. Dosage and how to take it

  • Dosage:

The usual recommended vaccination schedule includes basic vaccination in children from two months of age with 3 injections, between one and two months apart, then in the second five years the injection repeats one shot.

  • How to use:

With a syringe that does not have a needle attached, squeeze the needle separately into the injecting pump head by turning a quarter of the ring.

Re-entered by pumping a mixture of diphtheria, tetanus, immunity, immunity and mixed polio into a vial containing the Haemophilus influenzae type b type b vaccine in the form of a dry powder. Shake well until the dough is completely dissolved. After re-re-ioning, turbid white mixtures are normal.

The vaccine must be injected immediately upon re-refund.

  • Line used:

Intramuscular injection (IM)

The injection site is the front-side of the thigh (one-third of the middle) for babies and in the Delta muscle area for older children.

6. Contrainatrained

PENTAXIM should not be used in the following cases:

  • Hypersensitivity:
    • With any active substance of PENTAXIM
    • With any excipients
    • With glutaraldehyde, neomycin, streptomycin, or polymyxin B (used in the production process and can remain in very small amounts)
    • With whooping cough vaccine (cellless or "whole cell").
  • Have suffered a life-threatening serious reaction after vaccination or a vaccine with a similar composition
  • In case of fever or an urgent illness, re-vaccination must be postponed
  • Progressive encephaes
  • Have had encephages within 7 days of taking any dose of vaccine containing whooping cough antigen (cell-whole whooping cough vaccine or in-cell whooping cough).

7. cautious


Caution should be exercised when vaccinating 0.5ml Pentaxim Vaccine

PENTAXIM's immuno-birth may be reduced due to immunosuppressive treatment or immuno impaired. Therefore, it is recommended to wait until the end of treatment or cure before getting vaccinated. However, it is advised to still vaccinate children with chronic immuno-deterioration such as HIV infection, although antibody response may be limited.

If you have previously had Guillain-Barre syndrome or arm encephalitis after vaccination containing tetanus toxins, consider carefully between the potential benefits and possible complications of vaccination to decide whether to continue using a vaccine containing tetanus toxins. For young children who have not been vaccinated with full basic doses (less than three doses) it is usually recommended to adjust the vaccination schedule.

Do not inject into blood vessels: make sure that the needle is not in the blood vessels. Do not inject in the skin.

As with other injectable vaccines, caution should be exercised when injecting PENTAXIM for children with tingle reduction or bleeding disorders, as they are at risk of bleeding during intramuscular injection.

Before vaccination, medical history (especially history associated with immunization and any undesirable effects that have been experienced during immunization) and clinical examination must be carefully inquired.

If you have ever experienced any of the following symptoms that are temporarily considered to be related to vaccination, consider carefully when deciding to give a dose of the vaccine containing the next whooping cough component:

  • Fever above 40 degrees Celsius within 48 hours, without any other defining cause
  • Vascular or shock-like condition (tone reduction – decreased response) within 48 hours of vaccination
  • Persistent, difficult crying lasts more than 3 hours, occurs within 48 hours after vaccination
  • Seizures with or without fever, which occur within 3 days after vaccination

A history of high fever seizures that are not associated with a previous vaccination is not contraincular. For this case, it is especially important to monitor the temperature for 48 hours after vaccination and give a regular hypothermia for 48 hours.

A history of non-feverish seizures and unin connection with previous vaccinations must be consulted by a specialist before vaccination.

If there has ever been an edema reaction in the lower genus after vaccination containing haemophilus influenzae type b, then two vaccines: diphtheria vaccine – tetanus – whooping cough – polio and Haemophilus influenzae type b combination vaccine should be given at two different injection locations on two different days.

Just like when using other injectable vaccines, appropriate means of treatment should be prepared and closely monitored for the person injected for treatment as soon as an antisymic reaction occurs, even if it occurs.

PENTAXIM does not protect against infections caused by other Haemophilus influenzae types or the prevention of meningitis caused by other causes.

When injecting basic doses in infants born prematurely (gestational age 28 weeks or before 28 weeks), especially for children with a complete history of underdested respiratory system, for 48-72 hours after vaccination should be aware of the risk of temporary apnea and the need for monitoring of the baby's breathing. Vaccination offers many benefits in this group of children, so vaccination should not be rejected or delayed.

Effects on subclinical testing: since Hib shell polysaccharide antigen is excreted in the urine, a positive urine test can be seen within 1 to 2 weeks after vaccination. During this period, other tests should be performed to determine Hib infection.

The vaccine is not applicable to pregnant and lactation women. PENTAXIM is only used in children.

8. Undesirable effects

  • The most common reactions are irritation, at the injection site there are red circles, hard nodules larger than 2cm. These signs and symptoms are common within 48 hours after injection and can last 48-72 hours. They usually cure themselves without specific treatment
  • Body reactions: fever, agitated, drowsiness, sleep and eating disorders, diarrhea, vomiting, crying difficulties and stretching. Rarer, urticaria, skin rash, fever seizures, or fever-free seizures can be seen within 48 hours of injection
  • Decreased muscle enterm or episodes of muscle edd off – a decrease in reactions has been reported
  • After vaccination containing haemophilus influenzae type b, swelling reactions of lower genuss have also been reported. These reactions are sometimes accompanied by fever, pain and fuss.

Overdose and how to handle:

There is no data on vaccine overdose, no vaccine-in-command overdose. Actively monitor for timely action.

9. Shelf life

36 months from the date of manufacture The shelf life of the Vaccine is in written on the label and case.

10. Storage and removal

  • How to store: Keep out of reach and reach of children.

Store at temperatures from +2 degrees Celsius to +8 degrees Celsius (in the refrigerator).

  • When to remove:
    • Do not freeze
    • Do not use after the expiration date in written on the label, on the box
    • Do not use it if the vaccine is abnormally colored or has a strange
    • Do not dispose of the drug in drains or household trash cans. The product is no longer in use or the waste must be treated in accordance with applicable regulations.

Share99 International Health Hub is offering a package vaccination program with a variety of vaccines for a variety of subjects, from infants, young children, adults, women before and during pregnancy.
Particularly in December 2019, Share99 is free of charge for newborn Hepatitis B vaccination (immediately after birth) for babies when registering for the Package for children from 0-1 year old or from 0-2 years old.

For direct advice, please click hotline number or register online HERE. In addition, you can register for remote consultation HERE

Reference source: According to information approved by the Drug Administration of Vietnam on August 28, 2018.


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  • Five vaccines to be given to women after the age of forty

About: Minh Quynh

b1ffdb54307529964874ff53a5c5de33?s=90&d=identicon&r=gI am the author of I had been working in Vinmec International General Hospital for over 10 years. I dedicate my passion on every post in this site.


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