Adrenth myeloma increases catecholamine secretion

The adrenoid myeloid glands are where mainly the production of the hormones catecholamines (adrenalin, noradrenalin,…) that play a role in increasing the functioning of the cardiovascular system. Adrenthic myeloma increases catecholamine secretion is a condition that enhances the secretion of adrenthinal gland hormones, causing effects on the cardiovascular system.

1. Clinical symptoms of adrenth myeloma

  • Adrenthic myeloma is seen mainly in adults, 10% is seen in children aged 6-14 years with more frequency of disease in boys than girls.
  • The frequency of appearance of 30-40% of tumors found on both sides or in many places.
  • The cause of the disease is mainly catecholamine tumours that cause hypertension, which is cyclical and continuous later.
  • Characteristic symptoms of the disease are numerous headaches accompanied by signs of increased in-skull pressure. During the hypertension there will be severe headaches, blueness, sweating, possible convulsions.
  • Between bouts of blood pressure the sick child may be normal, but the body is thin, poorly eaten, slow to grow, dry skin, cold purple genus, wrinkled fingers.
  • Blood pressure increases much up to 180-260/120-210mm Hg.
  • Big heart, visual edema, arterial spasms
  • Greatly affects the visual function: gradual decrease in vision, blurred vision leads to the risk of complete blindness or permanent blindness.

Hypertension in patients with renal impairment

Hypertension in patients with adrenous myeloma

2. Sub-clinical symptoms of adrenth myeloma

2.1. Catecholamin test in adrenth myeloma diagnosis

The catecholamin test in the urine is a test to diagnose adrenth myeloma. This is a test to measure and evaluate the concentration of a group of hormones in the urine including epinephrine, norepinephrine, metanephrine and dopamine. These hormones are commonly known as catecholamin.

Catecholamin is made up of nerve tissue, typically the brain and athetic glands. The role of catecholamin is to prepare the best psychological state for the body in the face of traumatic or dangerous situations (e.g., attacked or life-threatening).

The main catecholamins in the body will be decomposed into vanillylmandelic acid (VMA), metanephrine, and normetanephrine. These decomposition substances will be eliminated through the urine. The catecholamin test in the urine also plays a role in measuring the amount of VMA, metanephrine, and normetanephrine thereby assessing the level of catecholamin in the blood.


Urine used as catecholamin test

2.2. The meaning of catecholamin index

High levels of catecholamines in urine and blood

– Increased concentrations of catecholamines in the blood and urine are associated with stress, which can be in touch from psychological reactions or stress from the external environment such as loud noise, extremely strong light or low blood glucose levels.

– High levels of catecholamines in the urine may also be caused by a deficiency of the monoamine oxidase enzyme (MAO), the enzyme that catalys the degeneration of catecholamines. When the gene encoding MAO is mutation, MAO is produced without the function of converting catecholamines, which significantly increases the concentrations of catecholamines in the blood and catecholamines in the urine.

– Extremely high levels of catecholamines (also known as catecholamine poisoning). Extremely high levels of catecholamines in the urine and in the blood, can occur in such fields as:

  • Central nervous system injuries are caused by irritation or by damage to certain encephaties in the brain trunk, especially brain 60s that affect the sympathetic nervous system. In emergency medicine, this condition is called the accumulation of catecholamines in the urine.
  • Neuroendocrine tumors in the adrenth (chrome-loving cell tumors), a condition that can be treated completely.


Catecholamin testing should be performed at a reputable medical facility

3. Treatment of adrenth myeloma

  • Specific treatment: Medical treatment, root tumor removal will cure the disease. Relapse is still possible to treat adrenthic myeloma removal.
  • Blood pressure should be maintained during surgery and after surgery for several days until the blood pressure returns to normal
  • Post-surgery monitoring.
  • Perform a test to re-evaluate the concentration of VMA or catecholamin in the urine after the lumpectecting surgery, if the blood pressure does not decrease, it is necessary to check again in time because it may be caused by the failure to remove the adrenthic myeloma.
  • 3-6 months and 1 year after re-examination of catecholamines in the urine in case of the risk of recurrence.

The adrenoid myeloid glands directly affect the cardiovascular system. Therefore, as soon as there are symptoms of adrenthic myeloma, you need to immediately go to a medical facility for examination and treatment advice. To register for examination and treatment at Share99 International Health Hub, you can contact Share99 Health System nationwide, or register for an online examination HERE


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About: John Smith

b1ffdb54307529964874ff53a5c5de33?s=90&r=gI am the author of I had been working in Vinmec International General Hospital for over 10 years. I dedicate my passion on every post in this site.


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