Learn the IGF test that evaluates the function of the vesic gland

The article was consulted professionally by Master, Dr Do Thi Hoang Ha – Biomedistry Doctor – Laboratory Department – Share99 Hai Phong International Hospital.

The sysal gland is an endal gland that is extremely important to the body, playing a role in directing the functioning of most other end end endal glands. Although it is only about the size of a pea and weighs about 0.5g, it is a place to excrete a lot of hormones.

Insulin-like growth factor-1 (IGF-1, short for "insulin-like growth factor-1"), also known as Somatomedin-C, has an insulin-like structure, encoded by the IGF-1 gene – along with growth hormone (GH) secreted by the pital glands, which promotes the development of the whole body and the growth of bones, normal tissues in particular. The main role of IGF-1 is to promote cell division (mitosis) and differentiation of cells in different tissues. IGF-1 is produced by the liver, bone muscles as well as many other types of tissue in the body under the stimulation and conditioning from the hormone GH. Therefore, IGF-1 plays a central role for all GH activities, stimulating the development of the whole body, especially the growth of the bone system and the production of lean muscle mass.

Since GH is released into the bloodstream throughout the day, it is difficult to explain the results from a single GH test. Unlike GH, thanks to the characteristic that the level is always stable at all times of the day, IGF-1 reflects excess and GH deficiency. This makes IGF-1 a useful indicators of average GH levels. Therefore, IGF-1 testing is often used to help diagnose growth abnormalities, assess GH deficiency or GH excess.

IGF-1 is produced throughout life; The highest rate of PRODUCTION IGF-1 occurs during the growth phase of puberty. IGF-1 levels, such as GH, are usually low at birth, increasing gradually as the child grows, peaking at peaks at puberty and then gradually declining in adult life. Deficiency of GH and IGF-1 can occur when the remnant gland is dysfunctional that depletes the entire sysathinal hormone (sysathinal insular inslebilience) or by a meathoma, causing damage to GH synthetic cells. In addition, IGF-1 deficiency also occurs when the body is insensitive to GH, which can be primitive (heredity) or second to conditions such as malnutrition, thyroid failure, sex hormone deficiency or severe chronic diseases, severe malnutrition accompanied.

If IGF-1 deficiency occurs early in life, usually as a result of GH deficiency, bone growth as well as comprehensive development of the body is inhibited, which leads to a child of small stature, lower than that of another child of the same age, late puberty. In adults, a decrease in IGF-1 production can lead to low bone density, less muscle mass and disorders of blood lipid levels.

Cons, when GH and IGF-1 are redundant can cause abnormal development of the skeleton and signs, symptoms of giant disease and enlarged head disease. In children, the bones will grow longer, becoming a very tall person with large paws and hands. In adults, extreme disease causes bones to thicken and soft tissues, such as the nose, ears will swell, fissicular pain, erectile dysfunction or menstrual disorders. Both of these conditions can lead to disorders of other muscles such as the heart, liver, kidneys, increased risk of cardiovascular disease, high blood pressure, diabetes mellitus, degenerative arthritis and reduced life expectancy.

An IGF-1 test can be used when there is one of the following purposes:

• Determination of growth hormone (GH) deficiency. Although this is not a greedy test for diagnosis of GH deficiency, IGF-1 may be required along with GH stimulation tests to provide more information.
• Track abnormal results on other hormone tests
• Evaluation of pitinane function (e.g., in addition to the same apothlar shell-stimulating hormone (ACTH) , in addition to Prolactin or FSH and LH to help diagnose pitinous dysfunctions and a decrease in pital hormone (pitinous instability).
• Detect excess GH and help diagnose and monitor for head and genus diseases and giant diseases.

The IGF-1 test is in place, which may be at the same time as other hormone concentration tests in the GH stimulation test, when:

• Children with symptoms of GH deficiency, such as slow growth, low stature
• Children with symptoms of late puberty
• Adults with symptoms that are suspected to be caused by GH deficiency, such as decreased bone density, fatigue, decreased exertion, and lipid concentration disorders
• Suspected pathology of the sythal gland
• Periodically monitor patients who are being treated with exotic GH
• Periodically monitor patients after treatment of mesathoma with surgery or chemotherapy, radiotherapy to assess the recurrence of the tranquila gland tumor.

More rarely, an IGF-1 test may be in place, along with a GH inhibitor test, when examining a child with symptoms of a giant disease or for adults with signs of head and genus enlarged disease.

The IGF-1 test measures the concentration of the hormone IGF-1 in the blood. Blood samples will be collected by inserting needles inserted into the veins in the arm, similar to regular blood tests.

In general, the patient does not need any preparation before performing this test. In cases where it can be done at the same time as other tests, it is possible that the person needs to fast for at least 12 hours before sampling.

Test tubes containing the product will be inserted into the machine and the entire procedure will be performed automatically, until the test is printed. Therefore, after taking blood, the patient can work again as usual, leave and make an appointment to return for the results.

Any results of the IGF-1 test must be considered in each specific context. Some people may have GH deficiency but still have normal IGF-1 levels.

Normal concentrations of IGF-1 must be considered in the specific state of each person in terms of age and gender.

4.1 Lower than normal IGF-1 concentrations

Reduced IGF-1 levels are likely due to GH deficiency or GH insensitiveness.

If it occurs in children, GH deficiency will cause low stature and developmental delay, At this time, the child should be treated with the addition of GH from the outside. However, in adults, IGF-1 levels will tend to decrease as they get older. Even so, if IGF-1 is below the psychological level in the general population of the same age group, this should also be thought of as a result of a GH deficiency or gh insymity.

If suspected IGF-1 reduction is due to reduced saddle gland function (resta cathing failure), some other enderthal glands and the hormone that regulates the rea gland will need to be evaluated next to decide the appropriate treatment. Impaired saddle function may be due to genetic defects or may be caused by the consequences of damage to the quiet gland after conditions such as injury, infection or autoimmunity.

In addition, impaired IGF-1 levels can also be found in malnourished patients such as anorexia erm, chronic kidney disease or chronic liver disease,…

4.2 Higher than normal IGF-1 concentrations

Higher than normal IGF-1 concentrations are associated with an increase in GH production. Due to the change in GH levels throughout the day, the IGF-1 test is considered a reflection of the average GH amount, not the actual amount of GH in the blood at the time of sampling the IGF-1 measurement. Accordingly, if GH is produced a lot, the level of IGF-1 will stabilize at a high maximum in the blood.

Increased levels of GH and IGF-1 are normally biological during puberty and pregnancy but most commonly due to a (usually benign) mesathoma.

If IGF-1 is measured to still increase after surgery to remove a tranquila gland tumor, the intervention considered may not be entirely effective. Other treatments such as medications and/or additional radiotherapy will need to be considered. In case IGF-1 levels have returned to "normal direction" showing that the treatment is effective, the patient's still glands no longer produce excess GH, long-term monitoring is also extremely necessary, detecting an increase in IGF-1 concentrations in order to know early the likelihood of recurrence of the tranquila gland tumor.

In summary, although the sathline is very small and deep in the brain, the function of this endococular gland can still be detected by measuring IGF-1 levels in a simple, easy-to-perform blood test. At this time, the result will be a good answer to the patient's condition and help guide positive intervention correctly.

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SEE MORE:

• Symptoms of meathoma
• Consequences of impaired saddle function
• Rest assured: Causes, Symptoms, Diagnosis and Treatment