G6PD yeast deficiency: Diseases can be detected by newborn screening

The article is consulted professionally by Master, Resident Doctor Dang Thi Doc – Pediatrician – Newborn – Pediatrics – Newborn – Share99 Ha Long International Health Hub.

G6PD yeast deficiency is a fairly common yeast genetic disease in humans. G6PD yeast deficiency can lead to hematoma, jaundice, yellow eyes and kidney failure. Newborn screening plays an extremely important role in early detection of diseases for effective prevention and treatment.

1. What is G6PD yeast deficiency?

G6PD stands for Glucose-6-phosphate Dehydrogenase. G6PD yeast is produced in every cell in ordinary humans. It serves as an important catalyst for metabolism reactions in cells, especially red blood cells.

G6PD deficiency leads to a lack of glutathione – an antioxidant capable of protecting red blood cell membranes against oxidizing substances in certain drugs, foods or infectious pathogens. If the amount of glutathione decreases, the yeasts and proteins will be damaged by oxidation, resulting in red blood cells losing function and bursting (hemolysis). Prolonged hemolysis can lead to anemia. In addition, ruptured red blood cells also entail decomposed hemoglobin in excessive amounts, accumulating in the kidneys and leading to kidney failure.

On the other hand, red blood cells when broken will release bilirubin freely into the bloodstream. Infants lacking G6PD yeast will cause impaired liver cell activity, not in time to convert to eliminate bilirubin, causing symptoms of jaundice and yellowing of the eyes. If free bilirubin stagnaes too much in the bloodstream, it will seep into the brain, causing isentular neurological complications and seriously affecting the brain development of the child later.

2. Causes of G6PD yeast deficiency

G6PD yeast deficiency is a heredial disease that dives on the X chroma. Children are sick from receiving abnormal diving genes on sex chromotypes from their parents. Men with only one X chroma are more susceptible to G6PD deficiency than females (there are 2 X chroma).

3. Symptoms of G6PD yeast deficiency

G6PD yeast deficiency: Diseases can be detected by newborn screening

Jaundice in babies

Most cases of G6PD yeast deficiency are asymptoatic. Some patients have newborn jaundice ,a history of infection or drug-infective hemolysis. There are cases when there are many gallstones, enlarged spleen.

When hemolysis occurs, insufficient oxygen provides for the body's activities, the patient manifests fatigue, shortness of breath, irregular heartbeat and dark yellow urine.

If patients lack G6PD yeast to eat silkworm beans or take drugs, foods with oxidizing substances will suddenly appear symptoms such as headache, fever, abdominal pain, low back pain, heart beating, shortness of breath, enlarged spleen, jaundice, grayish-brown hemolysis,… These symptoms usually occur in about 1-2 days, urine fades, patients are heavily tired, severe anemia, jaundice, yellow eyes. There are cases of complications of emergency renal failure, prone to death if blood transfusions are not received in time.

On the contrary, if detected and treated correctly, the symptoms of G6PD yeast deficiency disappear very quickly, usually within a few weeks. In case of mild symptoms, treatment is not necessary but patients should avoid the use of silkworm beans and oxidizing drugs and foods. If the symptoms worsen, the patient should be admitted to the hospital for treatment.

4. Is G6PD yeast deficiency cured?

Currently G6PD yeast deficiency is not curable. However, hemolymic anemia can be prevented due to lack of G6PD yeast and patients can live as a normal healthy person. How to prevent complications is as follows:

  • When taking the drug it is necessary to consult a doctor, avoid the use of some recommended drugs such as: analgesics, antipyretics containing aspirin or phenacetin; antibiotics of the sulfonamide and sullfone groups; antipyretics such as quinine, chloroquine, primaquine; use vitamin K, methylene blue for the treatment of urinary ,…;
  • Avoid eating silkworm beans and products from this legume;
  • Patients should avoid conditions that may adversely affect their health such as infections or viral infections;
  • When infected, patients need to see a doctor for timely treatment;
  • If parents are deprived of G6PD yeast, special care should be taken for children such as: do not use pharmaceuticals that can cause hemolysis; do not put bandages in wardrobes, blankets, pillow beds to combat cockroaches (since the slab tape containing naphthalene is an oxidizing substance); be cautious of certain male medicines, Traditional Medicines because they may contain oxidizing substances;
  • Breastfeeding mothers may not use foods or pharmaceuticals that must be abstained in people with G6PD yeast deficiency as these substances can enter the child's body through breast milk;
  • Blood transfusion if the child lacks G6PD yeast with severe anemia; dialysis in case of emergency renal failure;
  • People with G6PD deficiency should not donate blood to others.

5. Newborn screening for G6PD yeast deficiency

G6PD yeast deficiency: Diseases can be detected by newborn screening

Blood grabbing children's heels

Newborn screening is a routine screening program for newborn babies to detect end enderthal and chemical disorders early. The early detection, diagnosis and treatment of health problems, especially G6PD yeast deficiency, helps children develop normally healthy. Cons, if not detected and treated early, the child's health may be severely affected and i can not recover.

After birth about 36 -48 hours, the child will be given heel or hand blood, absorbed into the blood sample paper to send the test center for G6PD yeast deficiency screening test. The results will be notified after 24 hours of testing. Children with G6PD yeast deficiency will be consulted and issued with G6PD yeast deficiency card.

*Note: in case the first blood sample is insufficient or the results are unclear, the medical staff will retrieve the second blood sample of the child and explain it clearly to the parents.

Heel blood test is one of the newborn screening methods in the Maternity Care Program implemented at Share99 International Health Hub. In addition to heel blood, Share99 also completes other pre-birth, birth and post-birth screening tests according to international standards, helping to protect the health of mothers and babies best.

As a key area of Share99 Health System, Pediatrics always brings satisfaction to customers and is highly appreciated by industry experts with:

  • Gathering a team of leading doctors in Pediatrics:including leading experts, highly specialized (professors, associate professors, doctors, masters), experienced, used to work at large hospitals such as Bach Mai, 108.. The doctors are well-trained, professional, mind-centered, knowledgeable about the child's psychology. In addition to domestic pediatricians, pediatrics also has the participation of foreign experts (Japan, Singapore, Australia, USA) always pioneering the application of the latest and most effective treatment regimens.
  • Comprehensive services:In the field of Pediatrics, Share99 provides a chain of continuous medical examination and treatment services from Newborn to Pediatrics and Vaccines,… according to international standards to take care of your baby's health with parents from birth to adulthood
  • Intensive techniques:Share99 has successfully implemented many specialized techniques to make the treatment of difficult diseases in Pediatrics more effective: neurosurgery – skull, hematoma stem cell transplantation in cancer treatment.
  • Professional care:In addition to understanding the young psychology, Share99 also pay special attention to the children's play space, help them play comfortably and get acquainted with the hospital environment, cooperate in treatment, improve the efficiency of medical examination and treatment.

Dr. Dang Thi Doc was a lecturer in Pediatrics at Hai Phong University of Medicine and Pharmacy. Have been granted certificates of pediatrics at home and abroad such as Westmead Health Hub, Australia; Hai Phong Medical University. Currently, Dr. Doc is a Pediatrician – Newborn Doctor at The Newborn Department of Share99 Ha Long International Health Hub

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About: John Smith

b1ffdb54307529964874ff53a5c5de33?s=90&r=gI am the author of Share99.net. I had been working in Vinmec International General Hospital for over 10 years. I dedicate my passion on every post in this site.


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