What is nesting failure (RIF) in in viin in vism fertilization?

Over the past three decades, in visiator fertilization (IVF) has helped millions of women around the world conceive healthy babies. Although IVF success rates have always improved, however, many IVF cycles end in frustration in couples because the embryo at first seems normal, but after implantation into the uterus, the embryo cannot nest and cannot develop into a fetus. When implant failure occurs in multiple IVF cycles, the patient or couple is called a continuous nesting failure (the name is recurrent implantation failure and abbreviated as RIF).

Currently, obstetrician experts have not agreed on the definition of RIF. The most commonly used definition is failure after 3 transfers of workpieces with workpieces that can be of high quality. RIF consists of cases where the embryo has been implanted but cannot nest leading to failure, before the fetal sac can be detected by ultrasound. With the introduction of pre-embryonic genetic testing for chromochromic abnormalities (PGT-A), the definition of recurrent miscarriage and stillbirth can be supplemented with additional cases including consecutive nesting failures after three euploid chromoid embryo transfers, meaning that the number of chromoids in the cell is a multiple of n including the case of 2n, n, multiple multiples.

Many known factors contribute to the failure of nesting in in viin in vism fertilization. Known factors include the age of the parent, the genetic problem of the embryo, abnormalities of the uterus including birth defects, fibroids and polyps, chronic infections and inflammation of the ovary ducts as well as internal lining tissue of the uterus (endometriosis), autoictial factors, hormone abnormalities, obesity and environmental toxins including mothers who smoke, use alcohol and drugs.

As women get older, the number of eggs decreases and increases the proportion of eggs with genetic abnormalities. It is impossible to nest and the rate of bio-pregnancy increases with the mother's age, especially in women 38 years and older. However, RIF can occur, even with embryos considered normal in terms of chroma, age is only a contributing factor to RIF.

For any woman or couple with RIF, evidence-based assessment should be carried out that is both time-saving and cost-effective. By a comprehensive review including the history of diseases and reproduction of both parents, an assessment of genetic, endocular and immune factors, a detailed assessment of the uterus, ovary ducts and ovaries. Advanced sperm testing can be performed in some cases RIF.

Currently, there are many treatments that are commonly used and combined to help reduce nesting failure rates such as hormones, anti-coature drugs, treatment of diseases of the uterus or pelvis, antibiotic therapy and IVF combined with pre-implantation genetic testing (PGT) that may be the appropriate treatment for some couples.

Share99 Assisted Reproduction Center with seasoned experience and high expertise, modern facilities … have successfully developed and applied advanced techniques to improve nesting ability in in viinal fertilization, genetic diagnosis before embryo transfer, freezing ovules,embryos, sperm conservation reproduction … In addition, the Center has been successful in 2 very new areas in Vietnam such as supporting couples with thalassemia genes to give birth to healthy children; ovarian tissue freezing for patients with meta meta metasized bowel cancer before surgery and chemotherapy.

To register for examination and treatment at Share99 International Health Hub, you can contact Share99 Health System nationwide, or register for an online examination HERE.

Reference source: Rbmojournal.com; Rmany.com