Group B syseptic infection in women with a pregnancy of 35-37 weeks and treatment regimen

Article by Doctor of Laboratory Department – Share99 Danang International Health Hub.

Mother-to-child transmission of group B sysoping mainly occurs during labor or when the amniotic fluid breaks prematurely. Currently, with the application of a backup antibiotic treatment regimen based on the results of screening for vaginal diseases in women during pregnancy at the age of 35-37 weeks, the rate of infection and death from this pathology is significantly reduced.

Group B streptococcus (Streptococcus agalactiae or Group B streptococcus (GBS) is a bacterium considered to be the caus agent of newborn infection with the highest incidence and mortality in the US. Since the 1970s, the disease accounts for 30-40% and up to 50% in the 1980s, cases of newborn infections are caused by GBS. Approximately 1.5 babies per 1,000 babies living in GBS are diagnosed with GBS, with about 10% of babies diagnosed with GBS dying.

1. Mechanism and pathogenicity of GBS

Group B streptococcus streptococcus, which is a Gram-positive bacterium, common in a woman's gastrointestinal tract and genital tract, usually does not cause symptoms of the disease (healer carries bacteria).

  • In ordinary people: GBS can cause urinary tract infections.
  • In pregnant women: In women in labor through intrusive and pathogenic GBS genital lesions such as GBS causes inflammation of the post-calving lining of the uterus.
  • In newborns: Because the bacteria capable of synthesizing prostaglandin E2 causes inflammation of the amniotic membrane and causes premature newborn infections such as miscarriage, stilldeath, premature amniotic rupture,premature calving. Infection from the mother during labor due to pregnancy inhalation or swallowing amniotic fluid, vaginal fluid, skin lesions in the child when passing through the calving tube. The disease occurs in the first months of a child's life with a common clinical condition of sepsis,pneumonia, encephalitis – meningitis,osteomyelitis … resulting in death or severe neurological remth hit.

Premature babies 36 weeks

Group B syseposis can cause amnioticitis and early newborn infections

2. Backup strategy

Prevention strategies include: GBS implant screening for vaginal disease or urine testing in women during pregnancy at 35-37 weeks of gestation to detect risk subjects and use of antibiotics in labor with this subject.

Some studies have shown tremendous applied effects from the use of backup antibiotics such as:

  • A 21% reduction in the incidence of group B syscal infection in the mother.
  • Reducing the rate of med mother-to-child transmission leads to a 70% reduction in early newborn infections.

3. GBS backup antibiotics in labor as recommended by CDC 2010

GBS backup antibiotic injections are insularly insular:

  • History of childbirth with GBS infection.
  • There is GBS in vaginal or urine epidemics during this pregnancy.
  • GBS screening in vaginal epidemic patients is positive at weeks of gestation 35-37.
  • It is unclear what gbs infection is during labor and one of the symptoms:
  1. Labor before 37 weeks
  2. Amniotic ≥ 18 hours
  3. Temperature ≥ 380C

No GBS backup antibiotics are in dinhd:

  • Presenting with pre-pregnancy GBS infection (unless vaccination is in place in this pregnancy).
  • Have GBS in vaginal or pre-pregnancy urine (unless vaccination is in place in this pregnancy).
  • Screen for GBS negative vaginal translation, regardless of whether there are risk factors in labor.
  • Caesarean section when the amniotic membrane is intact, regardless of GBS infection or gestational age.

Antibiotics for prevention in labor:

  • Penicillin is the first option, which can be used ampicillin instead.
  • Women who are mildly allergic to penicillin can be replaced by cefazolin.
  • If strongly allergic to penicillin can be replaced by vancomycin or clindamycin.

What kind of iron should pregnant women choose

Penicillin is the first option, can be used ampicillin instead

4. Group B Sys sysysle-screening (GBS) results from vaginal epidemic disease in pregnant women with gestational age 35-37

From January 2019 to December 2019, the Micro-Laboratory of Share99 Da Nang International Health Hub performed group B sysent examination (GBS) screening from 1172 samples of vaginal epidemic disease in pregnant women with gestational age of 35-37 weeks.

As a result, there were 193 samples of group B sysoccal isolation (GBS) bacteria. That's 16.5 percent.

One problem raised here is: Should clindamycin antibiotics be used as a GBS Backup Antibiotic as recommended by CDC 2010?

According to statistics of antibiotic results made in the above 193 specimens at the Microbial Laboratory of Share99 Danang International Health Hub, the rate of GBS resistance to clindamycin has reached 70%. Therefore, the selection of antibiotics according to the results of antibiotics has always played an essential role in the treatment.

At Share99 International Health Hub, there is a full maternity service as a solution to help pregnant mothers feel secure because there is a team of doctors throughout the pregnancy. When choosing a full-service maternity, a pregnant woman can:

  • The process of pregnancy is monitored by a team of specialists
  • Regular examination, early detection of abnormalities
  • Package maternity for the convenience of childbirth
  • Infants receive comprehensive care

To register for examination and treatment at Share99 InternationalHealth Hub, you can contact Share99 Health System nationwide, or register for an online examination HERE


  • Lynne S.Garcia, Henry D. Isenberg (2007), "Microbiology procedures handbook, third edition and 2007 update"
  • Pham Thi Thanh Hien (2011), "Infectious diseases during pregnancy", Medical Publishing House.
  • Centers for Disease Control Prevention (2010), "Prevention of Perinatal Group B Streptococcal Disease: Revised guideline from CDC".
  • Centers for Disease Control Prevention (1996), "Prevention of Perinatal Group B Streptococcal Disease: a public health perspective".
  • Nguyen Thi Tuyen (2007), Sysm," Medical Microbiology", Medical Publishing House.
  • Neal R. Chamberlain, "The big picture: Medical microbiology"


  • What is GBS and why are pregnant women tested?
  • What is the AFI amniotic fluid index and what does it mean?
  • Implications of group B sysyseptic test (GBS) in pregnant women


  • Implications of group B sysyseptic test (GBS) in pregnant women
  • What is GBS and why are pregnant women tested?
  • Group B syseptic infection in women with a pregnancy of 35-37 weeks and treatment regimen

About: John Smith

b1ffdb54307529964874ff53a5c5de33?s=90&r=gI am the author of I had been working in Vinmec International General Hospital for over 10 years. I dedicate my passion on every post in this site.


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