Cause of failed day 5 embryo transfer

The article was consulted professionally by Master, Resident Doctor Nguyen Thi Tam Ly – Clinician – Center for Assisted Reproduction – Share99 Times City International Health Hub.

When eggs and sperm fit together, the embryo will be formed (usually this process takes place in the ovulation in your body). After that, the embryo divides quickly and comes to the uterus during the embryonic stage and interacts with the endo will for nesting. Nesting is the dialogue of embryos and endometrials. Good embryos and endometrial at the receiving stage or "nesting window" will increase the success rate.

There are 3 main reasons for the failure of the embryo transfer:

• Workpiece quality.
• The quality of the lining of the uterus.
• Unfavorable environment (health, physical health of the mother is not good or mentally too stressful)

Pregnancy, childbirth, whether in the form of natural fertilization or in vism in vicular fertilization, depends greatly on the age of the mother. By the standard number and quality of eggs (it is possible together with sperm to form healthy embryos). Basically women's psychology decreases over time, especially when women pass the age of 35. The higher the mage age, the greater the abnormal ovule rate and the poorer the quality of the embryo. If the egg quality is good, the more embryos form, which leads to the opportunity to transfer the mother's embryo more times in 1 cycle of egg stimulation.

Embryo quality is evaluated based on factors: Evenity in embryo size, soy cell fragmentation, embryonic 6th layer for embryos day 3 and based on the size of the follicle sinuses, ICM cell mass (growing into a fetus) and TE cell layer for the embryo day 5.

Type 1 embryos are embryos of the best quality, when introduced into the body will have the highest rate of development into pregnancy. Type 2 workpieces are of medium quality, while type 3 workpieces are of poor quality.

How is the lining of the uterus of quality for transferring embryos? The lining of the uterus has a thickness on the start date for the best Progessteron from 8-12mm, with the image on the ultrasound having a 3-leaf shape and good perfuscage. With state-of-the-art ultrasound systems and experienced ultrasound doctors at Share99 International Health Hub, pre-embryo transfer dopple ultrasound has helped clinicians determine the date for the correct progesterone, contributing to increasing the success rate for each embryo transfer.

Nesting is the interaction of embryos and the lining of the uterus. In 1 cycle, the lining of the uterus receives nesting embryos only for a certain period of time called the "nesting window". In order for the embryo to cling and develop in the uterus, the embryo must be transferred to the uterus in the "nesting window".

During the fresh embryo transfer cycle, the embryo is transferred into the uterus on the 3rd or 5th day after the ovulation (the day of ovulation), which coincides with the implant window of the natural menstrual cycle. During the transfer of frozen embryos, the embryo is transferred into the uterus after 3 or 5 days of use of progesterone depending on the age of the embryo.

In addition to the "nesting window", local immune elements of the lining of the uterus also play a very important role. Nesting in the uterus is the miracle of creation. Although a strange individual with half of his genetic set, the mother's uterus is willing to receive and nourish without disposal, the phenomenon of disposal of the graft as cases of organ transplantation (kidneys, liver). The most miraculous thing is that in women who have to ask for eggs, ask for embryos to be mothers, these live germs are completely strange to the mother's uterus, but are still received in harmony with the mother through the immune system. However, the ability of the mother to receive embryos depends on the local immuno-conditioning of the lining of the uterus through the action of immune factors such as "killer" cells, natural kiler cells, lymphocytes, cytokines.

The ERA test assesses the nesting window of the lining of the uterus and the local immunosmmunity test of the matrice lining of the uterus is performed at Share99 assisted reproduction center, contributing to an increase in the success rate after embryo transfer, giving hope to couples who fail to nest multiple times.

Embryo transfer should be stopped when you have a fever, have medical conditions or have inappropriate conditions such as stress, stress,fatigue etc.

To ensure that embryo transfers are less likely to fail, it is best to choose a guaranteed medical facility and do not hesitate to discuss health problems with your doctor for successful IVF results.

Master, Resident Doctor Nguyen Thi Tam Ly graduated with a major in General Medicine from Hanoi Medical University in 2015 and graduated with a Master's degree, Resident Doctor in Obstetrics and Gynecology also from Hanoi Medical University. With the strength of expertise in assisted reproduction, Dr. Ly has worked at the National Health Hub of Obstetrics and Gynecology and currently, Dr. Ly is working at the Center for Assisted Reproduction, Share99 Times City International Health Hub.