Combination of estrogen and progestin (ovarian hormone therapy)

Estrogen and progestin are female hormones. They are secreted by the body to ensure normal sex development and maintain the menstrual cycle in the age of reproduction in females.

1. Why use estrogen and progestin?


Reasons to use estrogen and progestin

The ovaries begin to reduce estrogen production after menopause. Estrogen is in dinhary supplements to compensate for the body's natural estrogen deficiency. Estrogen helps alleviate the symptoms of menopause, such as hotness, abnormal sweating, chills, fatigue or dizziness. Progestin is used to reconcile the effects of estrogen.

Some reasons to prescribe estrogen:

  • Compensates for the amount of estrogen deficiency due to insufficient production by the body, such as menopause. Estrogen also helps to improve a condition that appears in the genital skin that is atrophy of the or vaginal atrophy.
  • Helps prevent osteoporosis when women go through menopause.

Estrogen can also be prescribed by a doctor in many other situations.

There is currently no medical evidence to support the view that using estrogen helps patients become youthful, help smooth skin or delay the appearance of wrinkles. There is also no evidence that using estrogen when menopause relieves emotional and neurological symptoms, unless those symptoms originate from other menopause symptoms, such as hotness.

Drugs that combine estrogen and progestin are usually produced in the form of tablets or chewable tablets.

2. Factors to consider before using

  • Allergies: Inform your doctor if you have a history of allergies, especially drug allergies.
  • Advanced age: There are many drugs that are not adequately studied on the elderly, so it is not possible to determine exactly whether the drug works similarly to that on the body of a young person, nor can it be confirmed to the elderly whether the drug has any other undesirable effects or can cause any abnormal state. There is currently no special information when using estrogen and progestin in the elderly compared to other age groups.
  • Pregnancy: Estrogen and progestin should not be used during pregnancy or immediately after birth. Pregnancy usually does not occur at the stage of menopause women.
  • Lactation: Estrogen and progestin can enter breast milk, as well as can change the composition or reduce the amount of breast milk, therefore it is not recommended to use when breastfeeding.
  • Drug interactions: Although some medications should not be used together, in some cases two different drugs can be used together despite possible drug interactions. In this case the doctor may change the dose of the drug. If you are using any medication, you should inform your doctor to consider your drug interactions.

Use of estrogen and progestin in addition to any of the following medications is not recommended, and your doctor may discontinue prescribing or altering with another medication:

Use of estrogen and progestin with any of the following medications is generally not recommended, but may be used in certain mandatory cases, and your doctor may reduce the dose and change the duration of your medication:

    • Amifampridine
    • Anagrelide
    • Apalutamide
    • Aprepitant
    • Armodafinil
    • Boceprevir
    • Bosentan
    • Brigatinib
    • Bupropion
    • Carbamazepine
    • Ceritinib
    • Conivaptan
    • Dabrafenib
    • Darunavir
    • Dexamethasone
    • Donepezil
    • Efavirenz
    • Elagolix
    • Encorafenib
    • Enzalutamide
    • Erdafitinib
    • Eslicarbazepine Acetate
    • Etravirine
    • Fosaprepitant
    • Fosnetupitant
    • Fosphenytoin
    • Glecaprevir
    • Griseofulvin
    • Isotretinoin
    • Ivosidenib
    • Lesinurad
    • Lixisenatide
    • Lorlatinib
    • Lumacaftor
    • Mitotane
    • Modafinil
    • Nafcillin
    • Netupitant
    • Nevirapine
    • Oxcarbazepine
    • Paclitaxel
    • Paclitaxel Protein-Bound
    • Phenobarbital
    • Phenytoin
    • Pibrentasvir
    • Piperaquine
    • Pitolisant
    • Pixantrone
    • Prednisone
    • Primidone
    • Rifabutin
    • Rifampin
    • St John's Wort
    • Sugammadex
    • Theophylline
    • Tizanidine
    • Topiramate
    • Ulipristal
    • Valproic Acid
  • Other interactions: Some medicines should avoid eating certain feeds. Alcohol and tobacco can also cause interactions with the drug. Consult your doctor further.
  • Other issues: A history of the disease may have an effect on the use of the drug, please inform your doctor in full, especially if there is one of the following:
    • Bronchial asthma
    • Hyper or decrease in blood calci
    • Diabetes mellitus
    • epilepsy
    • Cardiovascular diseases
    • Kidney disease
    • Benign liver tumors
    • Lupus Erythem Erythem system
    • Migraine headache
    • Porphyria – estrogen can make the disease worse
    • Cardiovascular thromboembolysis (or formerly caused by estrogen use)
    • Breast cancer
    • Bone cancer
    • Cancer of the uterus
    • Uterine fibroids
    • Changes in the genitals or vaginal bleeding for unknown reasons
    • Endometriosis
    • Gallstones
    • High cholesterol or triglyceride levels
    • Liver disease
    • Acute pancreatitis
    • Thyroid mitigation
    • Vision changes
    • Convex eyes
    • Double look
    • Loss of vision in part or completely

3. Use of estrogen and progestin

Combination of estrogen and progestin

Use estrogen and progestin should follow the doctor's prescribed.

Use estrogen and progestin should follow the doctor's prescribed. It is recommended to take the drug at a fixed hour of the day to avoid forgetting to take the drug as well as reduce the likelihood of undesirable effects.

When taking estrogen and progestin, the patient may appear nausea and vomiting in the first few weeks, however will disappear on its own. This can be reduced or prevented by taking medication during or immediately after meals.

If you forget to take your medication, or take it as soon as you remember. If the time of discovery of forgetting to take the drug is already too close to the time of taking the next dose, skip the forgotten dose, do not voluntarily double the dose of oral medication.

During treatment, it is necessary to periodically re-examine as prescribed by the doctor. If any abnormalities occur, immediately notify the doctor.

4. Undesirable effects of treatment with estrogen and progestin

Women rarely experience severe undesirable effects when treated with estrogen instead. Prolonged estrogen use has been reported to increase the risk of bowel cancer in meninged women. The risk seems to increase with the dose and duration of use. When only low doses are used and with a period of less than 1 year, the risk will be low. The risk is also reduced when estrogen is taken in combination with progestin. The link between estrogen use and breast cancer is disputed.

If any undesirable effects appear, immediately notify your doctor. The possible undesirable effects are:

  • common:
    • Breast pain or increased sensitivity
    • Dizziness, sensitivity to light
    • Headache
    • Fast weight gain
    • Lower genus
    • Vaginal bleeding
  • Rare:
    • Abnormal mass in the breast
    • Abnormal vaginal secrety
    • Breast secrete
    • Nausea, vomiting
    • Chest, groin, shin pain (especially calves)
    • Abdominal pain
    • Pelvic pain or heavier
    • Sudden or severe headache
    • Unexplained sudden shortness of breath
    • Failed
    • Suddenly difficult to say
    • Sudden changes in vision
    • Helpless limbs
    • Jaundice, yellow eyes

Some undesirable effects will disappear on their own without intervention. If one of the following undesirable effects does not run out or affects the patient's life, consult your doctor:

  • Back pain
  • Abdominal obstruction
  • Dizziness
  • tired
  • Flu-like symptoms
  • Depression
  • Muscle pain
  • vomit
  • Vactis

In the event of any abnormalities, the patient needs to consult a doctor as soon as possible.

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Article reference source:


  • Learn about combined contraceptives
  • What is Progestin?
  • Some side effects that may be encountered when implanting a contraceptive rod

About: Minh Quynh

b1ffdb54307529964874ff53a5c5de33?s=90&d=identicon&r=gI am the author of I had been working in Vinmec International General Hospital for over 10 years. I dedicate my passion on every post in this site.


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